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Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats
null
《医学前沿(英文)》 2015年 第9卷 第3期 页码 368-373 doi: 10.1007/s11684-015-0403-1
Glucagon-like peptide-2 (GLP-2) has potent anti-inflammatory effects and protects against experimental ischemia/reperfusion (I/R) injury in pulmonary, intestinal, and myocardial tissue. However, its protective abilities against I/R injury in the liver are unknown. We investigated the potential role of GLP-2 pretreatment on hepatic I/R injury in rats. A total of 24 rats were randomly divided into three groups (n = 8). The first group was the control group; the second group was the vehicle-treated hepatic ischemia/reperfusion (HIR, vehicle saline-treated) group; and the third group was the GLP-2 pretreated I/R (GLP2-IR) group. Each rat in the third group was intraperitoneally administered 5 μg GLP-2 for 5 d before the procedure. A portal triad was created to induce ischemia with a vascular atraumatic clamp. After 40 min, the clamp was released to initiate hepatic reperfusion for 6 h. Blood samples and tissue specimens from the liver were obtained. Alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels significantly increased in the saline-treated HIR group (P<0.001), whereas GLP-2 pretreatment significantly decreased their levels (P<0.01). Our data suggested that GLP-2 pretreatment may have a protective effect on liver I/R injury. However, dose-response studies are necessary to determine the most effective dose.
关键词: ischemia/reperfusion liver glucagon-like peptide-2 alanine aminotransferase
血清N-聚糖生物标志物诊断ALT水平正常慢性乙型肝炎患者显著肝纤维化和肝硬化的临床意义 Article
王林, 刘艺琪, 顾启馨, 张驰, 徐蕾, 王蕾, 陈翠英, 刘学恩, 赵鸿, 庄辉
《工程(英文)》 2023年 第26卷 第7期 页码 151-158 doi: 10.1016/j.eng.2023.03.008
本研究目的是探讨血清N-聚糖模型在285例丙氨酸转移酶(alanine aminotransferase, ALT)水平正常measurement, LSM)、基于4因子的纤维化指数(fibrosis index based on the four factors, FIB-4)和天冬氨酸转氨酶与血小板比率指数(aspartate aminotransferase-to-platelet
Recombinant aspartate aminotransferase-catalyzed synthesis of L-4-fluorophenylalanine
CHEN Meijuan, JIA Honghua, CHEN Yongsheng, JIANG Min, WEI Ping
《化学科学与工程前沿(英文)》 2008年 第2卷 第2期 页码 220-223 doi: 10.1007/s11705-008-0041-0
关键词: L-4-Fluorophenylalanine Asp-AT aspartate aminotransferase 4-fluorophenylpyruvate FPPA
Synthesis of depsipeptides from
Hongfei CAO, Yakai FENG, Heyun WANG, Li ZHANG, Musammir KHAN, Jintang GUO
《化学科学与工程前沿(英文)》 2011年 第5卷 第4期 页码 409-415 doi: 10.1007/s11705-011-1141-9
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标题 作者 时间 类型 操作
Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats
null
期刊论文
Recombinant aspartate aminotransferase-catalyzed synthesis of L-4-fluorophenylalanine
CHEN Meijuan, JIA Honghua, CHEN Yongsheng, JIANG Min, WEI Ping
期刊论文